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Forced diuresis in the management of barbiturate intoxication
Author(s) -
Strickler James C.
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196566693
Subject(s) - diuresis , excretion , barbiturate , urine , diuretic , renal function , chemistry , pharmacology , barbituric acid , renal physiology , kidney , chlorothiazide , medicine , endocrinology , biochemistry
The renal excretion of barbiturates is increased in both experimental animals and in patients heavily overdosed with these sedative drugs by enhancing the urine flow. The greatest increases in excretion as a function of urine flow occur with those long‐acting and intermediate‐acting barbituric acid derivatives which are, in therapeutic dosages, eliminated in part by the kidney. Alkalinization of urine further augments the renal excretion of the compounds with relatively low pKa values. Hemodialysis and to a lesser extent peritoneal dialysis more rapidly eliminate barbiturates, particularly the short‐acting derivatives, than does any diuretic regimen.