Premium
Abstracts
Author(s) -
Moser Robert Harlan
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196565667
Subject(s) - medicine , pyuria , nausea , chest radiograph , white blood cell , physical examination , leukocytosis , urine , tachypnea , urinalysis , vomiting , surgery , anesthesia , gastroenterology , radiography , tachycardia
A 31‐year‐old white woman with a urinary tract infection was given sulfisoxazol (dose undisclosed). After 9 days pyuria persisted. She was then given nitrofurantoin, 100 mg. 4 times a day. After 6 days she developed fatigue, nausea, cough, and fever to 102.2° F. The subject also complained of headache, myalgia, and thirst. Physical examination showed respirations 40 per minute and bilateral expiratory wheezes. A chest radiograph showed that prominent hilar shadows and bilateral patchy infiltration were more marked in the right. Pertinent laboratory data included white blood cells 17,200 per cubic millimeter; urine sediment showed 2 to 5 white blood cells and 1 to 3 red blood cells. Oxygen was administered followed by a reduction of tachypnea. Clinical and radiographic improvement permitted her discharge from the hospital after 4 days. Approximately 3 weeks after discharge the subject complained of feeling “feverish.” A urine specimen showed pyuria. She was given three doses of 50 mg. of nitrofurantoin. On the evening after the third dose there was recurrence of nausea, fever, and dyspnea. The patient responded rapidly to oxygen. Chest radiograph showed fluid in the minor fissure and major fissure on the right, increase in the bilateral infiltrates, and hilar enlargement. There was clinical and radiographic improvement over the next 2 months without specific treatment.