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A clinical comparison of the antipyretic potency of aspirin and sodium salicylate
Author(s) -
Seed John C.
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196563354
Subject(s) - potency , sodium salicylate , antipyretic , aspirin , pharmacology , medicine , significant difference , analgesic , chemistry , biochemistry , in vitro
In a study on adult patients with cancer and low‐grade fevers due to chronic infection, aspirin appeared to be 1.5 times as potent as sodium salicylate as an antipyretic. The difference in potency is probably due to the difference in pK a of the two acids.