Premium
Termination of migraine headache by a new anti‐inflammatory vasoconstrictor agent
Author(s) -
Sicuteri F.,
Michelacci S.,
Anselmi B.
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196563336
Subject(s) - ergotamine , medicine , vasoconstrictor agents , migraine , anesthesia , blood pressure , cerebrospinal fluid pressure , cerebrospinal fluid , vasoconstriction , cardiology , intracranial pressure
Indomethacin, a new nonsteroid anti‐inflammatory agent causes headache, a marked decrease in cerebrospinal fluid pressure, and an increase in retinal arterial pressure, while it produces little and inconstant change in the pressure of the carotid and brachial arteries. Despite the headache, indomethacin was investigated in sub;ects with vascular headache because of its vasoconstrictor action. Clinical improvement similar or slightly inferior to that with ergotamine was observed.