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Clinical experiences with thalidomide in patients with cancer
Author(s) -
Grabstald Harry,
Golbey Robert
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196563298
Subject(s) - thalidomide , medicine , cancer , nephrectomy , oncology , surgery , kidney , multiple myeloma
Thalidomide (N‐phthaloylglutamimide) was used as a screening agent in the treatment of 71 patients with a wide spectrum of cancers. The production of embryonic defects by this compound prompted us to use it as an anticancer agent. There was no evidence of ob;ective response in any except one patient with renal cell cancer whose pulmonary lesions disappeared after treatment. This patient had also had nephrectomy, and it is highly possible that this response represented spontaneous regression of pulmonary metastases after operation, an event preViously observed with this tumor.