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Drugs used in the treatment of glaucoma. Part II
Author(s) -
Leopold Irving H.,
Keates Edwin
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196562262
Subject(s) - benzalkonium chloride , cholinesterase , acetylcholine , glaucoma , pharmacology , potency , atropine , chemistry , cyanuric chloride , medicine , ophthalmology , anesthesia , biochemistry , chromatography , in vitro , organic chemistry
Parasympathomimetic drugs act like acetylcholine. This naturally released neurohormonal agent promptly loses potency in solution and is rapidly inactivated in tissues by the enzyme, cholinesterase. For these reasons it is not generally used in the management of glaucoma. Corneal penetration by acetylcholine is very poor, but it can be increased by use of a wetting agent such as benzalkonium chloride.