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Comparison of hyoscine‐ N ‐butyl bromide and atropine sulfate in man
Author(s) -
Brownlee G.,
Wilson A. B.,
Birmingham A. T.
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196562177
Subject(s) - atropine sulfate , atropine , bromide , anesthesia , heart rate , medicine , chemistry , pharmacology , blood pressure , organic chemistry
The effects of hyoscine‐N‐butyl bromide (20 mg. subcutaneously) and of atropine sulfate (0.6 mg. subcutaneously) were compared in a controlled, double‐blind study in man. Both drugs caused statistically significant increases in heart rate and decreases in salivation, but the extents and the time courses of the changes were difJerent for the two drugs. Changes in pupil diameter, near point of vision, and sweat gland activity were not statistically significant. The experiments were made by medical students as part of their training in pharmacology.