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Objecfive evaluation of antitussive agents
Author(s) -
Sevelius Hilli,
Lester Patrick D.,
Colmore John P.
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196562146
Subject(s) - medicine , citric acid , ideal (ethics) , intensive care medicine , pharmacology , anesthesia , chemistry , philosophy , organic chemistry , epistemology
Subjective evaluation of antitussives is unreliable. In the search for an ideal procedure for evaluation, several methods have been developed which use bronchial irritants for artificial cough production in selected subjects. The currently popular citric acid and the acetylcholine methods with healthy volunteers were re‐evaluated and in our hands were unsatisfactory. Abrief discussion of the use of electronic cough recorders in subjects with spontaneous coueb as the only other presently available objective procedure for evaluating the efficacy of antitussive agents is presented.