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Protection studies with sodium thiosulfate against methyl bis (β‐chloroethyllamine hydrochloride (HN2) and its ethylenimonium derivative
Author(s) -
Bonadonna Gianni,
Karnofsky David A.
Publication year - 1965
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19656150
Subject(s) - sodium thiosulfate , nitrogen mustard , nausea , vomiting , hydrochloride , sodium , chemistry , pharmacology , medicine , chemotherapy , anesthesia , biochemistry , cyclophosphamide , organic chemistry
Methyl bis (β‐chloroethyl)amine hydrochloride (HN2) and chlorimine picrylsulfonate derivative (CPS) were injected alone and with sodium thiosulfate (TS) in laboratory animals and in patients with widespread metastatic carcinoma in order to study the protective effect of TS on the bone marrow depression produced by HN2 and CPS. In rats and rabbits 1.0 Gm. per kilogram of TS gave complete protection against supralethal doses of CPS, whereas it provided little protection against lethal doses of HN2. In man, however, 200 mg. per kilogram of TS protected against daily doses of HN2 and CPS (2 to 3 times the usual daily dose) administered for several days to a total of 2 to 9 times the amount given in the usual course of treatment. Nausea and vomiting usually followed each injection of HN2 and CPS, and thus was not prevented by TS. With one exception, tumor regression in these metastatic carcinomas was not observed after the administration of either HN2 or CPS preceded by protective doses of TS. TS gives much better protection against CPS than against HN2 in rodents, but this difference, while suggested by our data, was not clearly defined in man.