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Analgesic studies of indomethacin as analyzed by computer techniques
Author(s) -
Sunshine Abraham,
Laska Eugene,
Meisner Morris,
Morgan Sydney
Publication year - 1964
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196456part1699
Subject(s) - crossover study , analgesic , placebo , aspirin , medicine , anesthesia , crossover , computer science , alternative medicine , pathology , artificial intelligence
A method of evaluating oral analgesics in a general hospital is presented. The competition between crossover studies and single dose studies has led us to compare a basic crossover design with a single dose design, and a computer program was developed from both paints of view. The patients included in this study had moderate or severe postoperative or fracture pain, and received indomethacin, aspirin, and a placebo on a random complete crossover basis. This study indicated that single dose data only yielded more reliable information and probably a more efficient design than the crossover technique. Furthermore, placebo varied in its effect, depending on its position in the study, and appeared more effective when administered as a second test medication. Fifty milligrams of indomethacin appeared to be an effective oral analgesic equivalent to approximately 600 mg. of aspirin.