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A comparison of the value of 200,000 I. U. tetanus antitoxin (horse) with 20,000 I. U. in the treatment of tetanus
Author(s) -
Vakil B. J.,
Tulpule T. H.,
Armitage P.,
Laurence D. R.
Publication year - 1964
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196456part1695
Subject(s) - tetanus antitoxin , antitoxin , tetanus , horse , medicine , significant difference , value (mathematics) , anesthesia , veterinary medicine , mathematics , immunology , toxin , vaccination , statistics , biology , microbiology and biotechnology , paleontology
Patients were allotted at random, after diagnosis, to receive either 200,000 I.U. or 20,000 I.U. antitoxin. The results were analyzed sequentially and the trial was stopped after 300 patients had been treated. There was no significant difference between the mortality rates in the two dosage groups.