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Studies with aspirin: Psychopharmacologic and methodologic considerations
Author(s) -
Krumholz Wilhelm V.,
Sheppard Charles,
Merlis Sidney
Publication year - 1964
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196456part1691
Subject(s) - latin square , mood , placebo , depression (economics) , aspirin , psychology , volunteer , analysis of variance , crossover study , medicine , clinical psychology , alternative medicine , chemistry , rumen , food science , pathology , biology , fermentation , agronomy , economics , macroeconomics
The comparative tranquilizing effects of aspirin, a compound containing acetylsalicylic acid, phenacetin, and caffeine, mephenoxalone, and a placebo were measured in 20 male volunteer subjects with the Discomfort and Clyde Mood self‐rating scales. A Latin‐square design was followed with each subject regulating the daily dose of medication according to his subjective reaction. Each subject took each compound during consecutive 2 week periods. These data were subjected to a complex analysiS of variance. Significant mean differences were found for the fearfulness and depression scales. Individual subjects responded differently to each medication but APC was significantly the most effective compound in reducing feelings of depression and fearfulness. Some pitfalls in using the Latin‐square and crossover designs in psychopharmacologic research are discussed.