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Hyperventilation syndrome
Author(s) -
Aronson Philip R.
Publication year - 1964
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196455553
Subject(s) - chlordiazepoxide , hyperventilation , medicine , meprobamate , diazepam , tranquilizer , anesthesia
The effects of five drugs‐diazepam, triflupromazine, butabarbital sodium; meprobamate, and chlordiazepoxide‐upon the electrocardiograms of 4 subjects with chronic hyperventilation were compared at rest and after 2 minutes of forced hyperpnea. Chlordiazepoxide was the only one which consistently appeared to inhibit the electrocardiographic alterations consisting of ST segment depression, and less frequently influenced the T wave lowering or inversion. The importance of avoiding the error of misdiagnosing coronary heart disease is emphasized. Exact mechanisms for the hyperventilation‐produced electrocardiographic distortions are not yet fully understood. A “blocking effect” by chlordiazepoxide upon certain areas of the central nervous system may postulate one factor. This medication may be useful in differentiating the electrocardiographic patterns of hyperventilations from those of organic cardiac origin. Similar additional applications of chlordiazepoxide and other psychotropiC agents merit further study.