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Sodium retention following diuretic therapy
Author(s) -
Rivera Alfonso,
Flores Alejandro,
Suárez Ma. Antonieta,
Chávez José Ma.
Publication year - 1964
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196453286
Subject(s) - aldosterone , diuretic , antagonist , endocrinology , sodium , medicine , diuresis , chemistry , receptor , kidney , organic chemistry
Thirty‐three experiments were carried out to investigate the period of sodium retention which follows sodium diuresis in a group of patients with cirrhosis, a patient with Addison's disease, and a normal control. Four experimental schemes were employed under strict metabolic conditions: a normal sodium intake without an aldosterone antagonist, a normal sodium intake with an aldosterone antagonist, a low‐sodium intake without an aldosterone antagonist, and a low‐sodium intake with an aldosterone antagonist. It was shown that in patients with cirrhosis, or normal controls with a “normal sodium intake,” the postdiuretic weight regain was greater than the diuretic‐induced weight loss. That aldosterone participates in this phenomenon was demonstrated in the experiments with an aldosterone antagonist in which the period of sodium retention was reduced and was altogether absent in the patient with Addison's disease, but reappeared when this patient received desoxycorticosterone acetate.