Premium
Respiratory effects of Tris (THAM) in acidosis and alkalosis
Author(s) -
Cosby Richard S.,
Swan David A.,
Mayo Mary,
Roberts David L.,
Richardson Thomas R.
Publication year - 1964
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196452185
Subject(s) - hypocapnia , acidosis , hyperventilation , alkalosis , respiratory acidosis , respiratory alkalosis , medicine , anesthesia , metabolic acidosis , ventilation (architecture) , hypoxia (environmental) , hypercapnia , pulmonary gas pressures , tris , hypoventilation , metabolic alkalosis , cardiology , chemistry , respiratory system , oxygen , biochemistry , mechanical engineering , organic chemistry , engineering
Tris is an effective, safe, rapidly acting amine buffer for the treatment of metabolic and mixed acidosis. It is useful in diminishing cardiac irritability associated with acidosis and in treating acidosis of cardiopulmonary bypass. This study reports the quantitative effects of Tris in 14 normal patients and 13 others with varying degrees of acidosis and alkalosis, primarily metabolic. In patients with a normal resting pH and in those with acidosis, the expected changes of hypoxia, hypoventilation, and hypocapnia appeared. In patients with initial alkalosis, hyperventilation and a tendency to increased pO 2 were comman. In the maiority of patients, particularly those with stable initial ventilation, controlled, mild alkalosis could be produced and maintained within narrow limits. Control of shifts in pH may be of value in the therapy of cardiac irritability associated with acidosis.