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Clinical evaluation of a new anabolic agent 7 α, 17 α‐dimethyltestosterone (bolasterone)
Author(s) -
Korst Donald R.,
Bowers Cyril Y.,
Flokstra John H.,
McMahon F. Gilbert
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196346734
Subject(s) - anabolism , placebo , anabolic agents , crossover study , anabolic steroid , excretion , medicine , pharmacology , drug , nitrogen balance , endocrinology , chemistry , nitrogen , alternative medicine , organic chemistry , pathology
The anabolic effects of bolasterone have been compared with other such agents and with a placebo by the use of a twin crossover method. By expressing human metabolic balance effects as differences between pretreatment and posttreatment nitrogen excretion values, the steroid was found to be 25 times as potent as fluoxymesterone, 80 times as effective as norethandrolone, and twice as effective as methandrostenolone. The anabolic effect of bolasterone was confirmed by a weight gain study which compared a placebo, a standard anabolic agent, and the test drug. Androgenic effects of bolasterone were not observed in these studies.