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Some experimental and clinical studies on cephalothin
Author(s) -
Herrell Wallace E.,
Balows Albert,
Becker Jean
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196346709
Subject(s) - microbiology and biotechnology , klebsiella pneumoniae , staphylococcus aureus , shigella dysenteriae , streptococcus pneumoniae , salmonella , penicillin , klebsiella , biology , proteus , pseudomonas aeruginosa , corynebacterium diphtheriae , antibiotics , escherichia coli , bacteria , virology , diphtheria , biochemistry , genetics , vaccination , gene
In vitro sensitivity studies indicate that cephalothin is highly active against both penicillin‐sensitive and penicillin‐resistant strains of Staphylococcus aureus. Strains of beta hemolytic streptococci, streptococcus viridans, Diplococcus pneumoniae, Corynebacterium diphtheriae, Neisseria, and Actinomyces are quite sensitive to its action. Enterococci are relatively resistant. Approximately half of the strains of Klebsiella pneumoniae studied were sensitive. Some strains of Escherichia coli were sensitive. Some strains of Salmonella, Shigella, and Proteus were sensitive; others resistant. Strains of Pseudomonas aeruginosa were resistant to its action. Strains of Salmonella typhi tested were found to be sensitive. Serum inhibition studies indicate that the serum of patients receiving cephalothin is bactericidal for resistant and sensitive strains of Staphylococcus aureus and for strains of beta hemolytic streptococci and Klebsiella pneumoniae. Its action against the gram‐negative rods is highly selective. Infections due to organisms that are found to be sensitice respond favorably to treatment.