Premium
The effects of drugs used in labor on the fetus and newborn
Author(s) -
Moya F.,
Thorndike V.
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196345628
Subject(s) - asphyxia , fetus , medicine , drug , placenta , pharmacology , pregnancy , obstetrics , anesthesia , physiology , biology , genetics
In his response to drugs, the newborn infant is qualitatively arul quantitatively different from the mother arul even the same infant several months hence. The newborn shows marked susceptibility to the depressant effects of drugs used in labor. This heightened sensitivity is related in part to increased permeability of the blood‐brain barrier, inefficient renal function, absence of microsomal enzymes necessary for drug metabolism, arul asphyxia and physical trauma associated with the delivery process. Drugs used during labor arul delivery are considered in terms of their transmission across the placenta arul pharmacologic effects on the fetus and newborn.