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Observations on the human pharmacology and addictiveness of methotrimeprazine
Author(s) -
Fraser H. F.,
Rosenberg D. E.
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196345596
Subject(s) - abstinence , medicine , anesthesia , sedation , naltrexone , abstinence syndrome , physical dependence , morphine , antagonist , psychiatry , receptor
Methotrimeprazine, a derivative of chlorpromazine, has been evaluated for addictiveness by subcutaneous administration to former opiate addicts. It does not induce morphinelike effects when given in single doses, and only partially suppresses abstinence from morphine. When given chronically its effects were disliked and it did not induce physical dependence. Therefore, it does not possess morphinelike addictiveness. Sedation and postural hypotension are conspicuous pharmacologic effects of methotrimeprazine, and may greatly impair its clinical usefulness. Insofar as evaluated, rectal body temperature, respiratory rate, and systolic blood pressure (horizontal) were not affected by methotrimeprazine. No extrapyramidal symptoms were observed. All subjects retained a good appetite, and showed a moderate gain in body weight while receiving methotrimeprazine chronically.