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Systemic and coronary hemodynamic effects of an amine oxidase inhibitor and of serotonin
Author(s) -
Rowe George G.,
Afonso Skoda,
Castillo Cesar A.,
Kyle John C.,
Leicht Thomas R.,
Crumpton Charles W.
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196344467
Subject(s) - serotonin , medicine , hemodynamics , blood pressure , hemoglobin , anesthesia , systemic administration , cardiology , heart rate , pulmonary arterial pressure , cardiac output , biology , receptor , microbiology and biotechnology , in vivo
The systemic arul corolUlry hemodYlUlmic e{fects of administration of pheniprazine were studied in dogs both on acute intravenous administration arul after aperiod of approximately 18 hours' pretreatment with the drug. No significant hemodYlUlmic changes occurred, although the arterial hemoglobin arul hernatocrit rose arul the body oxygen consumption teruled to be higher after pheniprazine. The hemodYlUlmic e{fects of serotonin were slightly increased after pheniprazine pretreatment in that the cardiac rate increased more, the arterial pressure decreased further, arul left ventricular work was reduced. When injected in the same dose into the left atrium of control animals, serotonin produced aresponse qualitatively similar to that during its right atrial administration. The relation of the present observations to the pathogenesis of the carcinoid syndrome and the therapy of angilUl pectoris is discussed.