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What does the laboratory worker expect from clinical trials?
Author(s) -
Bloch Hubert
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196343390
Subject(s) - medicine , drug , nausea , animal testing , intensive care medicine , clinical trial , pharmacology , anesthesia , pathology , ecology , biology
Methods of preliminary exploration of drugs are analyzed. There are serious limitations to preliminary testing in the animal and to the preclinical testing in man. Some acute drug effects cannot be determined by animal experimentation: unpleasant taste, slight nausea, color vision disturbance, tinnitus, dizziness, etc. Some chronic effects on the liver, bone marrow, and other organs cannot be detected in the animal because they are characteristically human and often are not detected in man until the drug is given to hundreds of thousands of patients. It is suggested that greater "buyer resistance" by physician and patient would lead to reduction in the number of new drugs and greater concentration on aspects of drug development and application that would make for greater safety in their use.