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Patient selection and stratification in therapeutic trials
Author(s) -
Laurence D. R.
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196343381
Subject(s) - homogeneous , selection (genetic algorithm) , stratification (seeds) , medicine , clinical trial , intensive care medicine , computer science , mathematics , artificial intelligence , biology , seed dormancy , botany , germination , combinatorics , dormancy
As drug therapy improves, it will become more and more important to be able to detect small differences in therapeutic effect. This can be done only on groups and, if such small effects are not to be obscured, the groups must be themselves wholly homogeneous, or else divided into homogeneous subgroups, either at the outset or at the end of the trial. This requires careful definition and discriminating selection of patients, matters the importance of which it would be difficult to overstress.