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Hemolytic effects of drugs and chemical agents
Author(s) -
Prankerd T. A. J.
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196343334
Subject(s) - chemical agents , mechanism (biology) , mechanism of action , drug , cell , chemistry , pharmacology , biology , biochemical engineering , biochemistry , epistemology , in vitro , philosophy , engineering
Three different modes of action may be envisaged by which red cells are destroyed in the body by chemical agents. In the first instance there may be a direct interaction between cell and drug, in the second the cell may be predisposed to damage by its own inherent chemical abnormality, whereas, in the third, cell destruction is brought about by the formation of a red cell antibody. These different mechanisms are discussed and, where possible, chemical agents known to produce hemolytic reactions are considered as illustrations of these mechanisms. Since our knowledge of pathogenesis must succeed our knowledge of the occurrence of disease, it is impossible in many instances to ascribe a particular mechanism to a particular agent. The rapid growth of knowledge in this field has revealed chemical bases for individual susceptibility to several groups of drugs and has had wide repercussions in other scientific fields.