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A comparison of the value of 200,000 I.U. tetanus antitoxin with 50,000 I.U. in the treatment of tetanus
Author(s) -
Vakil B. J.,
Tulpule T. H.,
Armitage P.,
Laurence D. R.
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196342182
Subject(s) - antitoxin , tetanus antitoxin , tetanus , medicine , value (mathematics) , pediatrics , statistics , immunology , mathematics , toxin , vaccination , biology , microbiology and biotechnology
In view of the lack of adequate data on the proper dosage of antitoxin in clinical tetanus, a comparison of two doses was undertaken. Patients were allotted at random after diagnosis to receive 200,000 I.U. or 50,000 I.U. antitoxin. Altogether 293 cases were included. Analysis of the results indicates that the lower dose is as effective as the higher.