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Estimating the acceptability of morphine and noracymethadol in postpartum patients
Author(s) -
Gruber Charles M.,
Baptisti Arthur
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196342172
Subject(s) - medicine , morphine , anesthesia , pain relief
Single oral doses of morphine and noracymethadol were administered to postpartum patients for the relief of pain. Change in pain intensity was found to be directly proportional and relief of pain was found to be inversely proportional to initial pain. Effectiveness was determined by summing these two estimates of analgesia. Drug effectiveness was estimated 1, 2, 3, 4, and 6 hours after administration. The frequency and intensity of other symptoms were estimated 6 hours after drug administration. A double‐blind control was used. Capsules containing blank were administered to 200 patients. Doses of 15, 30, 60, and 90 mg. morphine were administered to 50 patients (6 patients received 120 mg.). Doses of 2.5, 5, 10, 20, and 30 mg. noracymethadol were each administered to 50 patients (18 received 40 mg.).