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Pathologic physiology, pharmacology, and therapeutics of tetanus
Author(s) -
Laurence D. R.,
Webster, R. A.
Publication year - 1963
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19634136
Subject(s) - tetanus , medicine , tetanus antitoxin , antitoxin , neuromuscular blocking agents , central nervous system , pharmacology , toxin , intensive care medicine , anesthesia , immunology , biology , vaccination , microbiology and biotechnology
Experimental evidence for the routes of tramport of tetanus toxin from the site of its formation to the central nervous system is reviewed. The possible sites and mechanisms of action of toxin are discussed, and an attempt is made to correlate the mode of action with that of drugs used to suppress convulsions. Despite the total absence until recently of any valid therapeutic comparisom, an attempt is made to evaluate the principal controversial therapeutic techniques, including antitoxin, care of the wound, chemotherapy, central anticonvulsants, neuromuscular blocking agents, tracheostomy, and adrenocortical steroids.