Premium
Are sitosterols atherogenic?
Author(s) -
Lawn Bernard,
Portman Oscar W.,
Stare Fredrick J.
Publication year - 1962
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196236823
Subject(s) - curran , medicine , biology , botany
In the editorial which appeared in the July‐August, 1962, issue of this journal, the untoward effects and possible danger of various cholesterol‐lowering agents were discussed, and only dietary modifications were considered a safe approach. In the discussion of sitosterols, the authors of the editorial stated that no toxic effects had as yet been reported. However, they made reference to a report by Curran and Costello in 1956 and stated: “There is evidence that [sitosterols] can induce atherosclerosis in experimental animals.” The implication that this may also be the case in man is apparent from the leitmotiv of the editorial.