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Part XIX. Clinical judgment in clinical research
Author(s) -
Ingelfinger F. J.
Publication year - 1962
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196235685
Subject(s) - suspect , sort , yardstick , test (biology) , psychology , medicine , epistemology , computer science , philosophy , mathematics , paleontology , geometry , criminology , biology , information retrieval
Some of the most difficult problems encountered in studies of the effects of drugs are related to the measurement of these effects in man. Everyone attempting to assess the effects of drugs in man would like to lean on some sort of sound and accredited yardstick, or as Dr. Bross would say, “one would at least like to hang on to some sort of strong rubber band.” Thus, in evaluating drug effects, we rely upon techniques that have enjoyed some success and acceptance. Emphasis on technique, however, may distort our basic purpose; to quote Dr. Zubrod, “I suspect that at times tactics dictate or distort strategy.” Often, the available tests are used whether or not they are strictly applicable. Certainly, good clinical judgment is necessary to determine the adequacy of any test method for a proposed clinical pharmacologic study.