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Suppressive therapy of chronic bronchial infections
Author(s) -
Dowling Harry F.,
Lepper Mark H.,
Jackson George Gee
Publication year - 1962
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196235564
Subject(s) - medicine , penicillin , tetracycline , erythromycin , antibiotics , sputum , pneumonia , antibiotic therapy , oleandomycin , pharmacotherapy , surgery , microbiology and biotechnology , pathology , tuberculosis , biology
The studies of long‐term antibiotic therapy reported in the literature are reviewed. The best clinical and bacteriologic results were obtained with 1 to 2 Gm. of tetracycline administered each day. Lesser degrees of improvement were reported when smaller doses were given, when the antibiotic was administered twice a week, or when therapy was given for a portion of the year only. Penicillin therapy was considerably less effective, erythromycin therapy appeared totally ineffective, and oleandomycin‐penicillin therapy was more effective than penicillin but less so than tetracycline. Untoward reactions occurred in all regimens but, prOvided patients reported them promptly, were not serious. Tetracycline‐resistant staphylococci appeared in the sputum of an occasional patient during therapy with that antibiotic but did not cause any complications, except possibly the development of pneumonia in 1 patient.