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The eye as a pharmacologic laboratory
Author(s) -
Leopold, Irving H.
Publication year - 1962
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196235561
Subject(s) - desoxyribonucleic acid , virus , cornea , deoxyuridine , virology , biology , medicine , pharmacology , dna , ophthalmology , biochemistry
Recently, 5‐iodo‐2'‐deoxyuridine has been demonstrated by Kaufman, Nesburn, and Maloney to be effective in controlling a human virus disease. It is a readily available, relatively nontoxjc compound that acts by interference with the virus‐directed synthesis of desoxyribonucleic acid. The compound had been found only partially effective against experimental virus infections in tissue culture and against anomalous desoxyribonucleic acid synthesis in cancer, but successful trials were performed on herpetic infections in the cornea of the experimental animal and human eye. Demonstration in the eye may have wide applicability for desoxyribonucleic acid virus diseases, and subsequent investigations may‐lead to effective antiviral chemotherapy in body areas distant from the eye.