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Hemodynamics during rest and exercise before and after prolonged digitalization in normal subiects
Author(s) -
Schröder G.,
Malmcrona R.,
Varnauskas E.,
Werkö L.
Publication year - 1962
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196234425
Subject(s) - stroke volume , cardiac output , heart rate , hemodynamics , medicine , cardiology , rest (music) , pulse rate , pulse (music) , preload , oxygen pulse , anesthesia , blood pressure , vo2 max , detector , engineering , electrical engineering
Twelve normal men were given acetyldigitoxin or digitoxin by mouth for 1 to 3 weeks. Cardiac output by dye dilution technique, intravascular arterial and right atrial pressures, heart rates with electrocardiogram, and oxygen consumption were determined during rest and at different work loads before and after digitalization. Pulse rate fell and stroke volume and left ventricular stroke work increased at rest. During the most frequently used work load, the pulse rate fell. No other hemodynamic changes were observed after digitalization.