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Some pharmacologic actions of yohimbine and chlorpromazine in man
Author(s) -
Ingram Charles G.
Publication year - 1962
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196233345
Subject(s) - yohimbine , reserpine , atropine , chlorpromazine , pharmacology , psychology , anesthesia , medicine , receptor , antagonist
Yohimbine was found to produce psychic and autonomic changes resembling anxiety in man. Chlorpromazine, reserpine, amobarbital and atropine modified the response to yohimbine. Both reserpine and amobarbital reduced the drug's psychic and autonomic effect, while atropine decreased the pressor response to yohimbine. Chlorpromazine acted paradoxically, potentiating both psychic and autonomic responses.