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A model for the appraisal of glucose metabolism
Author(s) -
Seed John C.,
Acton Forman S.,
Stunkard Albert J.
Publication year - 1962
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196232191
Subject(s) - glucose homeostasis , carbohydrate metabolism , metabolism , principal (computer security) , econometrics , computer science , chemistry , mathematics , biology , biochemistry , endocrinology , diabetes mellitus , insulin resistance , operating system
A model for the appraisal of glucose metabolism is proposed in which glucose homeostasis is divided into three parts: a rate of glucose dispersion into its volume of distribution, a utilization rate, and a production rate. The interrelationships between these processes are formulated as differential equations and are numerically integrated for typical cases. An attempt is made to find the best numerical values for the parameters from a critical analysis of the literature in which data from man have been used as far as possible. The principal results include the demonstration of the efficacy of mathematical models for the quantitative appraisal of glucose metabolism. Specifically, our model suggests the properties of a metabolite which can serve as a feedback control mechanism for the production of glucose, it shows the need for nonlinear mathematics to represent threshold phenomena, and it pOints to gaps in our understanding of glucose homeostasis. The approach used in this model should be useful in the analysis of the effects of drugs on glucose metabolism as well as in the study of normal glucose homeostasis.