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Pharmacologic effects of intravenous vanillic acid diethylamide in man
Author(s) -
Miller Murray J.,
Hand B. Marvin,
Crellin J. Antrim
Publication year - 1961
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196125689
Subject(s) - anesthesia , respiratory rate , tonic (physiology) , blood pressure , stimulant , respiratory system , medicine , heart rate , pulse rate , pharmacology
Vanillic acid diethylamide, a respiratory stimulant, was injected intravenously in doses of 0.5 to 2 mg. per kilogram. Effects were noted within 30 seconds; they lasted approximately 10 minutes. There was an average increase in tidal respiratory volume of 48 per cent and in respiratory rate of 24 per cent. Electroencephalograms were made bejore and after administration. The drug led to diminution of alpha activity, scattered high voltage spikes, cerebral dysrhythmias, and in 1 patient a tonic seizure. There were no significant changes in pulse rate or blood pressure.