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III. The interaction of thiopental and oxymorphone during surgical anesthesia
Author(s) -
Keeri-Szanto M.,
Knaff M.,
Rondeau Y.
Publication year - 1961
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196124441
Subject(s) - oxymorphone , anesthetic , anesthesia , medicine , nitrous oxide , anesthetic agent , chemistry , opioid , oxycodone , receptor
An equipotent mixture of thiopental and oxymorphone was used with very satisfactory results to supplement nitrous oxide anesthesia in 44 cases of major surgical operation. The mixture proved easy to prepare and to handle. The mean anesthetic time/dose curve was established for this mixture and compared with corresponding data obtained earlier for the component drugs. According to the mathematical analysis, the anesthetic action of the thiopental‐oxymorphone mixture is additive rather than synergistic. A technique is presented for the semiquantitative rating of various anesthetic agents, and by these criteria, the thiopental‐oxymorphone mixture is a better intravenous anesthetic agent than either of the components.