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Clinical pharmacology of the tetracycline antibiotics
Author(s) -
Kunin Calvin M.,
Finland Maxwell
Publication year - 1961
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19612151
Subject(s) - antibiotics , tetracycline , clinical pharmacology , pharmacology , excretion , pharmacokinetics , absorption (acoustics) , distribution (mathematics) , medicine , chemistry , biochemistry , mathematical analysis , physics , mathematics , acoustics
Some of the relevant features of the clinical pharmacology of the tetracycline antibiotics are reviewed, and, in particular, the absorption, excretion, and disposition in the body of the four homologues that are currently available for clinical use are compared. The relatively minor differences in the chemical structure of these drugs are accompanied by significant differences in some of their physical properties and by some quantitative differences in their absorption, excretion, and distribution in the body, their activity against different bacteria, and their clinical toxicity.