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II. The limiting factor in the utilization of intravenous anesthetics during surgical operations
Author(s) -
KeeriSzanto Michael
Publication year - 1961
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19612145
Subject(s) - oxymorphone , anesthetic , anesthesia , medicine , potency , limiting , pharmacology , chemistry , mechanical engineering , biochemistry , oxycodone , receptor , opioid , engineering , in vitro
The construction of mean time/dose curves of intravenous anesthetic drugs during surgical operations under standardized conditions is a simple and sensitive way to determine the equipotent doses of anesthetic agents. Such curves were determined for meperidine and oxymorphone, and the results were compared with the corresponding data previously established for thiopental. In spite of differences in the anesthetic potency of these agents by a factor approaching 500, the mathematical characteristics of the time/dose curves correspond so closely as to suggest that under the conditions of this study, a common factor limits the drug requirements. Arguments are presented in favor of the hypothesis that the common factor might be the effective blood flow through the liver or the permeability of the hepatic cell membrane.