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Role of antihistamine therapy in diphenylhydantoin‐induced gingival hyperplasia: A clinical and histopathologic evaluation
Author(s) -
Paddison Richard M.,
Anthony Samuel,
Ferriss Gregory S.,
Welsh Ronald A.
Publication year - 1960
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196013316
Subject(s) - antihistamine , placebo , medicine , hyperplasia , grading (engineering) , chlorpheniramine maleate , dermatology , pharmacology , pathology , chemistry , civil engineering , alternative medicine , chromatography , engineering
Stimulated by the original report of Gaillard upon the favorable influence of chlorprophenpyridamine maleate on diphenylhydantoin‐induced gum hyperplasia, and the reports of Breg and Sturmer indicating that chlorprophenpyridamine maleate and other antihistamine drugs were of no effect on diphenylhydantoin‐induced gum hyperplasia, the authors have studied 35 patients with this condition to a marked degree. In spite of the work of the previous investigators, our evaluation was felt warranted because of our use of a carefully controlled double‐blind experimental technique. Our patients were given either chlorprophenpyridamine maleate or an identical‐appearing placebo. Placebo or antihistamine drugs were administered for a 17 week period, and clinical grading, photographic grading, and gum biopsies were performed upon each patient before and after the administration of the drugs. In a well‐controlled experiment we demonstrated that chlorprophenpyridamine maleatet produced no evident visual or histopathologic change in diphenylhydantoin‐induced gum hyperplasia.