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Laxative studies: I. Human threshold doses of white and yellow phenolphthalein
Author(s) -
Munch James C.,
Calesnick Benjamin
Publication year - 1960
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196013311
Subject(s) - phenolphthalein , laxative , medicine , traditional medicine , toxicology , chemistry , biology , organic chemistry , constipation
Studies of threshold laxative response were conducted on 15 males and 10 females between 20 and 45 years of age, by a double blind method over aperiod of a year. The threshold laxative dose of white phenolphthalein averaged 68 mg. for the males and 36 mg. for the females; for yellow phenolphthalein, 47 mg. and 32 mg., respectively. This study suggests that the factor of sex should be considered in establishing a threshold dose for this product.