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The stimulant effect of 2‐dimethylaminoethanol (deanol) in human volunteer subiects
Author(s) -
Murphree Henry B.,
Pfeiffer Carl C.,
Backerman Ivan A.
Publication year - 1960
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196013303
Subject(s) - volunteer , morning , placebo , stimulant , pulse rate , medicine , anesthesia , endocrinology , physiology , blood pressure , biology , alternative medicine , pathology , agronomy
A double blind comparison of deanol, 10 to 30 mg. base, as the tartrate salt was made with an identical placebo in 35 volunteer subjects. No significant changes from the controls were observed in blood pressures, pulse rate, muscle strength, hand tremor, vital capacity, or body weight. Blood cholesterol levels were not changed. Blood protein bound iodine showed a slight tendency to decrease at the start of therapy, but this was not statistically significant. Gastric acid secretion was not changed, although volume of secretion was. Of the psychological and subjective responses, the significant findings were an increase in muscle tone, better mental concentration, and changes in sleep habits which were (1) less sleep needed, (2) sounder sleep, and (3) absence of the customary period of inetficiency in the morning in the deanol‐treated group.