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Transposition of drug studies from laboratory to clinic
Author(s) -
Beyer Karl H.
Publication year - 1960
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196013274
Subject(s) - enthusiasm , value (mathematics) , transposition (logic) , medicine , intensive care medicine , engineering ethics , computer science , psychology , engineering , artificial intelligence , social psychology , machine learning
A serious consideration of the transposition of drug studies from laboratory to clinical medicine implies that it is impractical for the pharmacologist to assess directly in man the value of many different compounds as potentially useful drugs. This is based on the following considerations: (1) the safety of the patient, (2) the lack of suitable large patient populations and (3) a sufficient number of astute clinical investigators, (4) the impracticality of synthesizing sufficient quantities of thousands of compounds, and (5) the sheer lack of enthusiasm for going through this effort for wh at would necessarily be a largely unfruitful search for useful therapeutic agents. The tremendous advancements in chemotherapy in recent years bear testimony to the ever‐increasing success with which elegant drug research on laboratory animals can be transposed to man. The purpose of this editorial is to discuss some of the factors that determine success in this important, but poorly understood, area of research.