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Nitrofurantoin (Furadantin) in the biliary tract
Author(s) -
Feder Isidore A.,
Kahn Alvin I.,
Flores Angeles,
Tager Bernard
Publication year - 1960
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196012156
Subject(s) - nitrofurantoin , biliary tract , urinary system , medicine , drug , pharmacology , gastroenterology , microbiology and biotechnology , antibiotics , biology , ciprofloxacin
Twiss and his co‐worker's reported that the oral administration of nitrofurantoin produced bactericidal levels of the drug in the bile. The organisms which infect the biliary tract are frequently the same as those which infeet the urinary tract. They therefore inferred that nitrofurantoin should be a valuable agent in treating infections of the biliary tract. We were unable to eradicate infections in the biliary tract even though the organisms isolated from culture of the bile were sensitive to the action of nitrofurantoin in vitro. Therefore we decided to repeat the studies of Twiss and his associates. Following the oral administration of adequate doses of nitrofurantoin, the levels of this drug were studied in bile specimens obtained trom the gall bladder by T‐tube drainage and duodenal tube drainage. Blood levels were also determined. Nitrofurantoin levels were far below those obtained by Twiss. In no instance was there any bactericidal activity of nitrofurantoin observed at levels present in the bile during treatment. Nitrofurantoin is therefore ineffective in treatment oi infections of the biliary tract.