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Renal effects of hydrochlorothiazide in normal and toxemic pregnancy
Author(s) -
Assali N. S.
Publication year - 1960
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19601148
Subject(s) - chlorothiazide , hydrochlorothiazide , pregnancy , medicine , endocrinology , excretion , preeclampsia , renal function , obstetrics , diuretic , blood pressure , biology , genetics
The effect of hydrochlorothiazide was studied in 10 hospitalized patients (7 with pre‐eclampsia and 3 with normal pregnancy) and 48 ambulatory sub;ects (30 with normal pregnancy and 18 with toxemia of pregnancy). Hydrochlorothiazide increased the excretion of Na + , Cl − , K + , and water without any significant change in renal plasma flow or glomerular filtration rate. The increase in electrolyte excretion was more marked in the patients with toxemia of pregnancy than in those with normal pregnancy. On the basis of electrolyte excretion hydrochlorothiazide is approximately 10 times as potent as chlorothiazide in pregnant women. As in the case of chlorothiazide, the drug is more effective when edema is present.