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Cannabinoids suppress acute and anticipatory nausea in preclinical rat models of conditioned gaping
Author(s) -
Parker LA,
Rock EM,
Sticht MA,
Wills KL,
Limebeer CL
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.98
Subject(s) - nausea , vomiting , antiemetic , medicine , anesthesia , pharmacology , psychology
The sensation of nausea is one of the most debilitating human experiences. Current antiemetic therapies are effective in reducing vomiting, but are less effective in reducing acute and delayed nausea and are completely ineffective in reducing anticipatory nausea. Recent preclinical evidence using a selective rat model of nausea (conditioned gaping reactions) has revealed that cannabinoids have great promise as treatments for nausea and that their antinausea effects may be mediated by the interoceptive insular cortex.