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The Use of Stem Cell Therapy to Reverse Opioid Tolerance
Author(s) -
Li Fei,
Liu LiPing,
Cheng Kathleen,
Chen Zhongbo,
Cheng Jianguo
Publication year - 2018
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.959
Subject(s) - medicine , opioid , mesenchymal stem cell , transplantation , hyperalgesia , pharmacology , intensive care medicine , nociception , pathology , receptor
Opioid tolerance (OT) and opioid‐induced hyperalgesia (OIH) are major challenges in medicine. Here we report that transplantation of mesenchymal stem cells (MSCs) prevented and reversed OT and OIH in rats and mice. The preventive and therapeutic effects were long‐lasting and consistent across different assessment schemes. Both intrathecal and intravenous transplantations were effective and safe. This emerging therapeutic strategy has thus shown promise to impact clinical practice and improve the efficacy and safety of opioid therapy.