Premium
How Well Are We Applying Quantitative Methods to Reverse Translation to Inform Early Clinical Development?
Author(s) -
Heatherington Anne C.,
Kasichayanula Sreeneeranj,
Venkatakrishnan Karthik
Publication year - 2018
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.948
Subject(s) - translation (biology) , computer science , computational biology , chemistry , biology , biochemistry , messenger rna , gene
If we are to improve our low success rate and rising costs in the pharmaceutical industry, we need to use every tool available. Reverse translation can particularly inform discovery and early clinical development via appropriate quantitative integration of relevant data. This commentary reports on a crowd‐sourced survey (2017) that sought to evaluate the integration of reverse translation in pharma. The results indicate that these methods are being applied, to varying degrees, across most respondents.