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Commentary on “The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio”
Author(s) -
Rowland Malcolm,
Pang K. Sandy
Publication year - 2018
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.921
Subject(s) - clinical pharmacology , pharmacokinetics , clearance , drug , metabolic clearance rate , drug development , subject (documents) , pharmacology , medicine , intensive care medicine , nothing , computer science , epistemology , philosophy , urology , library science
Among pharmacokinetic concepts, clearance has been the most widely applied in clinical pharmacology and drug development. With so much written on the subject it might be thought that there is nothing more to say. So it is noteworthy that some basic aspects related to hepatic clearance, and specifically the most popular model, the well‐stirred model, have been challenged by Benet et al .[1][Benet, L.Z., ] This commentary examines the challenge and provides our views.