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Leveraging Humanized Animal Models to Understand Human Drug Disposition: Opportunities, Challenges, and Future Directions
Author(s) -
Choo Edna F.,
Salphati Laurent
Publication year - 2018
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.908
Subject(s) - disposition , drug , humanized mouse , pharmacology , drug development , computational biology , medicine , biology , psychology , microbiology and biotechnology , in vivo , social psychology
The utility of animal models in understanding drug disposition and extrapolating to human in a direct manner is limited, confounded by differences in enzyme and transporter substrate specificity and expression between species. Conversely, certain clinical pharmacology or mechanistic studies cannot be conducted for ethical and practical reasons. Thus, humanized animal models could be useful to bridge the gap between preclinical and clinical pharmacology and gain relevant insight into the determinants of drug disposition and drug–drug interaction (DDI).