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The Introduction and Clinical Use of Cardiac‐Specific Troponin Assays
Author(s) -
Antman Elliott M.
Publication year - 2018
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.773
Subject(s) - troponin complex , creatine kinase , myocardial infarction , lactic dehydrogenase , cardiology , medicine , troponin , troponin i , lactate dehydrogenase , enzyme , biochemistry , biology
The earliest biomarkers introduced to diagnose myocardial infarction (MI) such as aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) lacked cardiac specificity and were replaced by creatine kinase (CK), the CK‐MB isoenzyme, and ultimately the cardiac‐specific troponins (cTnT and cTnI). This has opened up the possibilities of ruling out MI more rapidly and also identifying patients with a chronic elevation of cTn and a poor prognosis in a range of cardiac conditions.