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Emerging Targets of Diuretic Therapy
Author(s) -
Cheng CJ,
Rodan AR,
Huang CL
Publication year - 2017
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.754
Subject(s) - pendrin , diuretic , reabsorption , pharmacology , transporter , medicine , heart failure , chemistry , endocrinology , kidney , biochemistry , gene
Diuretics are commonly prescribed for treatment in patients with hypertension, edema, or heart failure. Studies on hypertensive and salt‐losing disorders and on urea transporters have contributed to better understanding of mechanisms of renal salt and water reabsorption and their regulation. Proteins involved in the regulatory pathways are emerging targets for diuretic and aquaretic therapy. Integrative high‐throughput screening, protein structure analysis, and chemical modification have identified promising agents for preclinical testing in animals. These include WNK‐SPAK inhibitors, ClC‐K channel antagonists, ROMK channel antagonists, and pendrin and urea transporter inhibitors. We discuss the potential advantages and side effects of these potential diuretics.